Early in the offseason, Pietrangelo and the Golden Knights released a statement that Pietrangelo is dealing with a hip injury that would require bilateral femur reconstruction, with no guarantee of success. This week, the Golden Knights officially announced that he will be unavailable for the duration of the 2025-26 season and the playoffs. The 35-year-old Pietrangelo has 637 points (148G / 489A) in 1087 career games, leaving a notable void on the Golden Knights' blueline.

Perfetti suffered the ankle injury during the Jets' preseason finale after delivering a hit on Kevin Bahl in the second period. With Perfetti out to open the season, that opens a door in the Jets' top-6 and on the top power-play unit. Alex Iafallo is currently set to line up on the Jets' top powerplay unit.

Toews "tweaked something" in a preseason contest against the Minnesota Wild last Tuesday and finally returned to practiced on Sunday. After missing the entirety of the previous two seasons, recovering from injuries, Toews signed in the offseason with his hometown team. The veteran forward scored 31 points (15G / 16A) in 53 games in his most recent season in 2022-23.

Lundell suffered an upper-body injury in the Panthers' preseason game last Thursday, but will be in the lineup for the opener vs. Chicago. Lundell is poised for a breakout season as he tries to help fill the shoes of Aleksander Barkov, who is expected to miss the entire season. Lundell will open the season on a line with Eetu Luostarinen and Sam Reinhart and PP2.

Ekblad was hurt in Saturday's preseason finale, but head coach Paul Maurice said that he'll be in the lineup on opening night vs. Chicago. Ekblad will open the season on the top pair with Gustav Forsling and the top power-play unit in a two-defensemen look alongside Seth Jones.

Lafferiere was banged up in the Kings' preseason game last Thursday and missed the preseason finale on Saturday, but was a full participant in Monday's practice. The Kings are "optimistic" but said that is's "not a guarantee" that Lafferiere will be in the lineup on opening night when the Kings host the Avalanche.

Blackwood was on the ice Monday but won’t travel with the team for their one-game trip to Los Angeles. With him unavailable, expect Scott Wedgewood to start and Trent Miner to serve as backup. Blackwood’s status for Thursday’s home opener vs. Utah is also in doubt, though his participation in Monday’s practice is an encouraging sign that the injury isn’t long-term.

Luukkonen missed the majority of training camp due to a lower-body injury and will be sidelined for at least the first week of the regular season. If the 26-year-old is forced to miss significant time, a combination of Alexandar Georgiev and Devon Levi will likely handle the crease in Buffalo.

Kesselring left the Sabres' preseason game on October 1st after aggravating an injury that he'd been dealing with throughout camp. Sabres' head coach Lindy Ruff said that Kesselring will be re-evaluated on a week-to-week basis, effectively ruling him out for the start of the regular season.

Power suffered an undisclosed injury early in training camp and was expected to be ready for Buffalo's season opener, but has been placed on Injured Reserve and will be sidelined for at least one week. The 22-year-old Power is coming off a career-best season in 2024-25, scoring 40 points (7G / 33A) in 79 games. With Rasmus Dahlin locked into Buffalo's top powerplay unit, Power will likely spend most of the season quarterbacking the second unit upon his return.

It was announced earlier that Greenway would miss Buffalo's season opener with a lower-body injury, but the forward was also placed on IR on Monday and will miss at least the next seven days. It appears the 28-year-old's run of bad injury luck in Buffalo will continue this season after missing 128 games combined in his first three seasons with the Sabres.

With St. Louis off on Monday, they were unable to provide an update on Oskar Sundqvist after he left practice on Sunday with what appeared to be a lower-body injury. The 31-year-old is entering his third season in St. Louis and was batting for a bottom-six role before the injury. His status for St. Louis' opening night game vs. Minnesota remains uncertain.

Batherson suffered an upper-body injury earlier in training camp and will miss at least one more week after being placed on Injured Reserve. The 27-year-old right-winger is entering his eighth season in Ottawa after putting up career highs in points (67) last season across 82 games played. He will likely play an integral role in Ottawa's offence this season.

Kleven will begin the 2025-26 season on Injured Reserve, recovering from an undisclosed ailment. The 23-year-old defenseman played a career-high 79 games last season, averaging 14:28 time-on-ice and scoring 10 points (4G / 6A).

Vlasic had his preseason cut short due to a lower-body injury, and his status is unlikely for Chicago's season opener. The Blackhawks are expected to take eight defensemen to Florida, and Ethan Del Mastro is expected to take his spot in the lineup if he's unable to go.

Pospisil returned to practice on Thursday after suffering an injury in a preseason game the night before, but will not suit up for Calgary's season opener against the Edmonton Oilers after being placed on IR on Monday. The 25-year-old Slovak forward is entering his third NHL season after recording career highs in games played (81), points (25), and hits (301).

Huberdeau was ruled out of Calgary's opener earlier on Monday with an undisclosed injury and will now miss the next seven days after he was placed on IR by the Flames. The 32-year-old Huberdeau averaged 19:33 time-on-ice and had 62 points (28G / 34A) in 81 games last season, his most productive campaign with the Flames.

Samuelsson reaggravated an upper-body injury, sidelining him midway through training camp, but he could be ready to play in Buffalo's season opener after originally being ruled out. The 24-year-old is entering his sixth season with Buffalo after putting up career highs in goals (4), points (14), and games played (62) in 2024-25.

Chatfield was absent from practice on Monday due to an undisclosed injury but will likely be ready for Carolina's season opener on Thursday against the New Jersey Devils. The 29-year-old Chatfield was effective in a shutdown role for the Hurricanes last season, averaging 18:53 time-on-ice and recording 18 points (7G / 11A).

Anderson is battling an undisclosed injury and will begin the 2025-26 seasons on Injured Reserve. The 27-year-old Anderson was limited to only 18 games with the Blackhawks last season, averaging 12:24 time-on-ice and recording one assist.